Nucleic acid bioanalysis plays a pivotal role in the detection and quantification of nucleic acids within biological samples, ensuring the development of safe and effective therapies. It may also be used in the detection and identification of metabolites to better understand drug metabolism, bioavailability, and assess toxicity of a therapy.
Your single-source provider for bioanalysis of ASOs, siRNAs, guide RNAs, mRNAs, and more!
Services Overview
Extraction of nucleic acids from biofluids and tissues
Quantification by hELISA, LC, LC-MS, LC-MS/MS, and qPCR in the lower ng/mL range
Metabolic stability and identification of metabolites
Non-GMP and GMP analyses available
Method validation according to ICH M10
Multiple purification methods available
BioSpring has in-house analytical methods optimized to the highest specificity and sensitivity. Our internal standard LC-MS/MS method is a proven, reliable method that achieves high specificity and low variability across modalities. Check out our recent publications here.
Pharmacokinetic Investigations
Assessing drug substance concentration in animal biofluids and tissues:
Biofluids
Plasma
Serum
Blood
Urine
CSF
Sputum
Nasal fluid
Tissues
Brain
Heart
Liver
Spleen
Muscle
Kidney
Lung
Lymphatic tissue
More available upon request.
Toxicity Studies: From Early Preclinical to GLP Tox
We offer the complete bioanalytical package to support your toxicity studies, starting with the development of sensitive methods for quantifying nucleic acids in biological samples. At our dedicated laboratories in Frankfurt, we process animal tissue samples, carefully collecting, preserving, and analyzing the samples, with close adherence to compliance and regulatory guidelines. As a last step, we conduct a systemic evaluation of the data using advanced statistical techniques, in coordination with selected partners, and generate reports for regulatory submissions.
Our Workflow
Why Choose BioSpring
BioSpring offers comprehensive bioanalytical services for nucleic acids. We operate using a continuous improvement workflow to enhance quality, foster innovation, and reduce costs for you. Our expert bioanalytics team is ready to take on your project.
One-stop-shop for nucleic acid manufacturing, analytics, and bioanalytics!
Broadest industry experience of oligonucleotide analytical methods
In-house analytical methods optimized to achieve to the highest specificity and sensitivity
High flexibilitiy and short setup time
High confidence using latest mass-spectrometry techniques
